Enki™ is designed to make generating novel molecule structures easy. Expand your imagination in 4 easy steps

No data required. Just define your TPP and Enki does the rest. Enki is an ensemble of generative algorithms trained on decades worth of experimental data with proven results.

Define your TPP

Select your on-target(s), off-target(s), and other properties in minutes.

AXL
EGFRs
PIK3s
CDKs
VEGFRs
90+ kinases

The Enki™ Platform is the first commercially accessible foundation model for small molecules.

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Company

Founded in September 2019, we are a team of experienced AI/machine learning researchers and medicinal and computational chemists applying state of the art generative AI to drug discovery in close collaboration with biopharmaceutical partners to redefine the unit economics of drug discovery and development.

Our Team

We are a team of experienced AI/machine learning and business specialists applying state of the art generative AI to drug discovery in close collaboration with biopharmaceutical partners to bring new therapeutics to market across disease areas and positively impact lives.

Handol Kim

Mehran Khodabandeh, PhD

Peter Guzzo, PhD

Roslynn Drewitt-Lange

Marshall Drew-Brook

Marawan Ahmed, PhD

Jason Rolfe, PhD

Artem Cherkasov, PhD

Ali Saberali, PhD

Ahmad Issa, PhD

Board, Observers, and Advisors

John Boylan, PhDSAB Member (Cell Biology/Oncology drug discovery)

Nancy Harrison, PhDAdvisor (Strategy/ Commercial)

Mads Daugaard, PhDSAB Member (Oncology Biology)

Jennifer Hamilton, PhDAdvisor (Strategy/Commercial)

Robert N. Young, PhDSAB Member (Medicinal Chemistry)

Alexander Tropsha, PhDSAB Member (Cheminformatics)

Todd Farrell, PhDAdvisor (Strategy)

Frank Chang, PhDBoard Director

Funding, Partners & Investors

Founded in September 2019, we are a team of experienced AI/machine learning and business specialists applying state of the art generative AI to drug discovery in close collaboration with biopharmaceutical partners to bring new therapeutics to market across disease areas and positively impact lives.

Recent News & Events

Press Release

Variational AI announces generative AI project with Merck

Merck to evaluate Variational AI’s Enki™ generative AI platform to design novel and selective small molecules Vancouver, BC – January 25, 2024 – Variational AI, developer of the Enki™ generative artificial intelligence (AI) platform for drug discovery, today announced a project with Merck Research Labs supported by the CQDM Quantum Leap program. “We are pleased to announce Merck as an early-access user of our Enki™ Platform.” said Handol Kim, CEO, Variational AI. “Merck will evaluate Enki’s ability to generate novel small molecules on targets of their choosing. We built and trained Enki™ as a foundation model that generates novel, selective, and synthesizable lead-like structures. It designs novel molecules how other generative AI foundation models like DALL-E and Midjourney create novel images based on text prompts. In our case, a target product profile (TPP) is used as the series of prompts to describe the molecules in the language of chemistry. Enki™ then rapidly generates structures that meet the TPP.” “Adoption of AI for drug discovery is accelerating, but it is being led by companies using their proprietary AI to discover and develop their own assets.” Explained Kim, “With the Enki™ Platform, chemists do not need to develop their own generative AI…
Press Release

Variational AI Files Two US Provisional Patents for Potential COVID-19 Drug Created by Generative AI

Variational AI, developer of the Enki™ generative artificial intelligence (AI) drug discovery platform to redefine the economics of drug development, today announced that the company has filed two provisional patents with the United States Patent...
Press Release

Variational AI Adds Jennifer Hamilton as Advisor

Variational AI, developer of generative AI-based drug discovery platform for novel kinase inhibitors, today announced that it has added industry and scientific leader Jennifer Hamilton, Ph.D. as a company advisor.

Variational AI is hiring!

Please see open job listing below or contact us if you would like to join the team in the area of machine learning, computational medicinal chemistry, and business development.

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